Added: Westin Scheer - Date: 09.02.2022 13:20 - Views: 32423 - Clicks: 7049
Their average time on study was The patients were randomized to receive no further treatment patientspostoperative adjuvant chemotherapy with 5-fluorouracil, semustine, and vincristine MOF patientsor postoperative radiation therapy patients. Employing the proportional hazards model, a global test was used to determine the presence of treatment interactions.
Investigation of stratification variables employed in this study indicated that sex, and to a lesser extent age and Dukes stage, made individual contributions to Free local sex at caplan disease-free survival and the survival benefit from chemotherapy. When males were tested for age trend with the use of a logistic regression analysis, chemotherapy was found to be more advantageous in younger patients.
The global test for interaction to identify heterogeneity of response to radiation within subsets of patients was not ificant. In conclusion, this investigation has demonstrated a benefit from adjuvant chemotherapy MOF for the management of rectal cancer. The observed advantage was restricted to males.
Postoperative radiation therapy reduced the incidence of local-regional recurrence, but it failed to affect overall disease-free survival and survival. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. Search: Search. Advanced Clipboard. Display options Display options. Create file Cancel.
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Similar articles Randomized trial of postoperative adjuvant chemotherapy with or without radiotherapy for carcinoma of the rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R Wolmark N, et al. J Natl Cancer Inst. The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with Free local sex at caplan cancer. Johnston PG, et al. J Clin Oncol. Adjuvant postoperative therapy of gastrointestinal malignancies. Ilson DH, et al. Oncology Williston Park.
PMID: Review. Rougier P, et al. Ann Chir. See all similar articles. Cited by articles Phase II randomized trial of capecitabine with bevacizumab and external beam radiation therapy as preoperative treatment for patients with resectable locally advanced rectal adenocarcinoma: long term .
Salazar R, et al. BMC Cancer. Clinical Trial. Osterman E, et al. Cancers Basel. Downstaged ypTN0 rectal cancer after neoadjuvant chemoradiation therapy may not need adjuvant chemotherapy: a retrospective cohort study. Liao YT, et al. Int J Colorectal Dis.
Epub Oct PMID: Kunst N, et al. Cancer Epidemiol Biomarkers Prev. Epub Sep Wexner SD, et al. Clin Colon Rectal Surg. Epub Jul See all "Cited by" articles. Publication types Clinical Trial Actions. Comparative Study Actions. Randomized Controlled Trial Actions. Research Support, Non-U. Gov't Actions. Research Support, U. Gov't, P. MeSH terms Aged Actions.
Clinical Trials as Topic Actions. Combined Modality Therapy Actions. Female Actions. Humans Actions.
Male Actions. Middle Aged Actions. Postoperative Period Actions. Prognosis Actions. Random Allocation Actions.
Sex Factors Actions. Substances Semustine Actions. Vincristine Actions.
Fluorouracil Actions. Supplementary concepts MOF protocol Actions. Full text links [x] Silverchair Information Systems. Copy Download.Free local sex at caplan
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